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Chemical Name: Rasagiline
Azilect (Razagline) is a novel, potent, second-generation, selective, irreversible monoamine oxidase type-B (MAO-B) inhibitor that blocks the breakdown of dopamine, a substance in the brain needed to facilitate movement.
AZILECT (Razagline) is used for the treatment of Parkinson's disease as monotherapy (without levodopa) or as
adjunct therapy (with levodopa).
In Parkinson's disease there is a loss of cells producing dopamine in certain areas in the brain.
AZILECT enables increased and sustained levels of dopamine in these areas.
The development of rasagiline is part of a long-term alliance for co-development in Parkinson's disease and European marketing between Lundbeck and Teva.
Azilect® is a joint development of Teva and the Technion - Israel institute of Technology.
Azilect Side Effects:
Like all medicines, AZILECT can have side effects.
When AZILECT is taken as monotherapy (without levodopa) the following side effects have been
Very common (more than 10% of the patients): Headache.
Common (between 1-10% of the patients):Allergic reaction, Fever, Flu syndrome, Malaise, Neck pain, Angina pectoris, Anorexia, Dyspepsia, Abnormal results of blood tests (leucopaenia), Joint pain (arthralgia), Arthritis,
Depression, Vertigo, Rhinitis, Contact dermatitis, Skin carcinoma, Vesiculobullous rash, Conjunctivitis,
Uncommon (between 0.1-1% of the patients):Stroke (cerebrovascular accident), Myocardial infarct.
When AZILECT is taken as adjunct therapy (with levodopa) the following side effects have been
Very common (more than 10% of the patients): Abnormal movements (dyskinesia).
Common (between 1-10% of the patients):Abdominal pain, Accidental injury (primarily falls), Neck pain, Low blood pressure when rising to a standing position (postural hypotension), Anorexia, Constipation, Dry mouth, Vomiting
Weight loss, Joint pain (arthralgia), Tenosynovitis, Abnormal dreams, Difficulty in muscular co-ordination (ataxia), Prolonged muscle contractions (dystonia), Rash.
Uncommon (between 0.1-1% of the patients): Angina pectoris, Cerebrovascular accident, Skin melanoma.
Take AZILECT exactly as instructed by your doctor. You should talk with your doctor or pharmacist if you are unsure.
The recommended dose of AZILECT is one tablet of 1 mg taken orally once daily.
AZILECT may be taken with or without food.
If you take more AZILECT than you should:
If you think that you may have taken too many AZILECT tablets, contact your doctor or pharmacist
immediately. Take the AZILECT carton/bottle with you to show the doctor or pharmacist.
If you forget to take AZILECT:
If you have forgotten to take a dose of AZILECT take the next dose at the usual time. Do not take a
double dose to make up for the one you missed.
The generic alternative is not manufactured by the company that makes the brand product.
All prices are in US dollars.
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