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Zyloprim Information:

Zyloprim (Allopurinol) reduces the production of uric acid in your body. • Zyloprim (Allopurinol) is used to treat gout, increased levels of uric acid caused by cancer treatment, and kidney stones that are caused by high levels of uric acid. • Zyloprim (Allopurinol) may also be used for purposes other than those listed.

Zyloprim Side Effects:

If you experience any of the following serious Zyloprim side effects, stop taking Zyloprim (Allopurinol)and seek emergency medical attention: · Zyloprim side effects like (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); · blood in your urine or pain when you urinate; · a rash; · eye irritation; · fever, chills, or joint aches; or · severe nausea or vomiting. • Other, less serious Zyloprim side effects may be more likely to occur. Continue to take Zyloprim (Allopurinol)and talk to your doctor if you experience Zyloprim side effects like · upset stomach or diarrhea; · headache, dizziness, or drowsiness; or · an acute attack of gouty arthritis. • Zyloprim side effects other than those listed here may also occur. Talk to your doctor about any Zyloprim side effects that seems unusual or that is especially bothersome.

What other drugs will affect Zyloprim (Allopurinol)? • Taking ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox, others) may increase the risk that a rash will develop during allopurinol therapy. Tell your doctor that you are taking Zyloprim (Allopurinol)if you need to take ampicillin or amoxicillin. • Thiazide diuretics (water pills) may increase the amount of Zyloprim (Allopurinol)in your blood. Tell your doctor if you are taking a diuretic such as · hydrochlorothiazide (Hydrodiuril, Hygroton, HCTZ, others), · chlorothiazide (Diuril, others), · chlorthalidone (Thalitone, others), or · indapamide (Lozol). • Zyloprim (Allopurinol)may also increase the effects of the certain other drugs. Before taking allopurinol, tell your doctor if you are taking any of the following medicines: · azathioprine (Imuran), · mercaptopurine (Purinethol), · drugs used to treat cancer, · cyclosporine (Sandimmune, Neoral), · chlorpropamide (Diabinese), · warfarin (Coumadin), or · theophylline (Theochron, Theolair, Theo-Dur, others). • You may require a dosage adjustment or special monitoring if you are taking any of the drugs listed above. • Drugs other than those listed here may also interact with Zyloprim (Allopurinol). Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Zyloprim Directions:

The usual adult dose of Zyloprim (Alloprinol) to prevent a gouty attack is 200 to 300mg daily in mild cases and 400 to 600 mg daily in severe cases. Daily doses over 300 mg are to be taken in 2 to 3 divided doses with or after food. Maximum recommended daily dose is 800mg. Maintain adequate hydration (2-3 liters per day of fluids) through out the day unless instructed to restrict fluid intake.

Zyloprim Precautions:

Zyloprim (Allopurinol) may cause drowsiness, thus be cautious when performing hazardous activities that require alertness; do not drink alcohol while taking this medication; Zyloprim may predispose patient to antibiotic-induced skin rash if taken together. Acute gouty attacks may occur in the first 6 weeks of therapy with Zyloprim; inform your doctor immediately if you experience joint pain. Zyloprim may affect the blood level of some other drugs, if taken together and visa versa. Also some over the counter medications may influence the effectiveness of Zyloprim. Consult with your doctor and pharmacist about possible drug interactions. In some patients Zyloprim may cause hypersensitivity; report any skin rash immediately to your doctor.