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Chemical Name: Norethindrone Acetate and Ethinyl Estradiol
FemHRT (norethindrone acetate and ethinyl estradiol, NA/EE) tablets are the first hormone replacement therapy (HRT) combining estrogen and progesterone in a single pill taken once-a-day, everyday for the relief of menopausal symptoms and the prevention of osteoporosis.
FemHRT (norethindrone acetate and ethinyl estradiol, NA/EE) is a combination of hormones (estrogen and progestin) used to treat menopausal symptoms (e.g., hot flashes, vaginal dryness). FemHRT (norethindrone acetate and ethinyl estradiol, NA/EE) is also used to prevent bone loss (osteoporosis) in people at high risk. If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. There are several medicines (e.g. raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen/progestin HRT for osteoporosis. If you have other medical conditions as well and are prescribed estrogen/progestin HRT for more than one condition, consult your doctor about your treatment plan and its options.
FemHRT Side Effects:
FemHRT side effects that may go away during treatment, include dizziness, lightheadedness, headache, stomach upset, bloating, irritability, changes in sleep patterns, fatigue, nausea, weight changes, increased or decreased interest in sex, or breast tenderness. If FemHRT side effects continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience FemHRT side effects like mental or mood changes (e.g., severe depression, memory loss); calf pain or swelling; sudden severe headache; chest pain; trouble breathing; one-sided weakness; slurred speech; vision changes (e.g., change in contact lens fit, loss of vision); breast lumps; swelling of hands and feet; changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding); unusual vaginal discharge, itching, or odor; or yellowing of eyes or skin. FemHRT side effects are unlikely, but seek immediate medical attention if FemHRT side effects occur. Symptoms of an FemHRT side effects include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other FemHRT side effects not listed above, contact your doctor, nurse, or pharmacist.
KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using FemHRT. You should have a complete physical examination, including blood pressure measurements, breast and pelvic examinations, and a PAP test (for vaginal cancer), at least once a year. You should also have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately. DO NOT INCREASE YOUR DOSE, take FemHRT more often than prescribed, or stop taking FemHRT without checking with your doctor. BEFORE YOU HAVE SURGERY, or will be confined to a chair or bed for a long period of time (e.g., a long plane flight), tell the doctor that you are using this medicine. Special precautions may need to be taken in these circumstances while you are taking this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure your doctors and laboratory personnel know you are using this medicine. FemHRT side effects MAY CAUSE DIZZINESS. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Limit alcoholic beverages. FemHRT side effects include dark skin patches on your face (melasma). Exposure to the sun may make these patches darker. If FemHRT side effects like patches develop, consult your doctor about the use of sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths. SMOKING WHILE USING THIS MEDICINE may increase your risk of blood clots (especially in women over the age of 35). DO NOT USE FemHRT if you are pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your doctor immediately. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while using FemHRT because they may result in FemHRT side effects.
FemHRT warning: Combination hormone replacement therapy (estrogen and progestin HRT) should not be used to treat heart disease. Two-drug combination hormone replacement therapy can infrequently cause cancer of the breast, heart disease (e.g., heart attack), stroke, dementia, or blood clots in the lung (pulmonary embolism) or leg. Estrogens may also increase the risk of cancer of the ovary. These risks appear to depend on the length of time this combination is used and the amount of estrogen per dose. Therefore, two-drug HRT should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious side effects from long-term treatment. Discuss the risks and benefits with your doctor. If you use this medicine for an extended period, you should be evaluated at least once a year. See Cautions section. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are also taking corticosteroids (e.g., prednisone), hydantoins (e.g., phenytoin), warfarin, drugs which affect certain liver enzymes (CYP450-3A4 enzymes) such as azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, macrolide antibiotics (e.g., clarithromycin, erythromycin), phenobarbital, rifamycins, (e.g., rifampin), ritonavir, cimetidine, or St. John's wort. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including a family medical history (especially for breast lumps or cancer), asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of the eyes and skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids, endometriosis), cholesterol or lipid problems, gallbladder disease, excessive weight gain, certain blood disorders (porphyria), allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have undiagnosed abnormal vaginal bleeding, cancer (e.g., of the breast or ovary), blood clots, liver disease, or active/recent stroke or heart attack. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
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