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Chemical Name: Clindamycin/Benzoyl Peroxide
Clindoxyl Gel Information:
Clindoxyl® Gel was approved by TPP Canada in November 2001, and is indicated in the topical treatment of moderate
acne vulgaris characterized by comedones and papulopustules. This product is contraindicated in patients with a history of hypersensitivity to products containing clindamycin, lincomycin, benzoyl peroxide or any other component of the preparation. Relative contraindications also include: a history of regional enteritis, ulcerative colitis, or antibioticassociated colitis.
Clindoxyl Gel Side Effects:
In the three pivotal studies, 343 adverse events were reported on 255 patients. No significant difference in
frequency of adverse events between the treatment groups was noted. Of the 113 adverse events reported
with Clindoxyl®, nine were related to the study medication (7 cases of mild-to-moderate pruritus, erythema, and
dryness; 1 case of worsening of acne; 1 case of mild paresthesia). Overall tolerance was rated excellent in 94%
of the patients who were treated with Clindoxyl® Gel.
Clindoxyl® Gel, a combination of 1% clindamycin phosphate and 5% benzoyl peroxide, is efficacious and well tolerated in the treatment of moderate acne vulgaris. Furthermore, this combination product is more efficacious
than either agent individually.
All prices are in US dollars.
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