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Chemical Name: apraclonidine
Apraclonidine is a relatively selective alpha2-agonist. It lowers pressure by reducing the production of aqueous and is effective when used alone or in conjunction with other medications. In clinical trials with difficult to control glaucome patients, Iopidine® 0.5% ophthalmic solution provided additional reductions in IOP in many patients. Iopidine 0.5% is currently approved for short-term use to lower eye pressure in patients on maximally tolerated therapy.
Iopidine Side Effects:
The following adverse events, occuring in less than 2% of patients, were reported in association with the use of IOPIDINE Ophthalmic Solution in laser surgery: ocular injection, upper lid elevation, irregular heart rate, nasal decongestion, ocular inflammation, conjunctival blanching, and mydriasis. The following adverse events were observed in investigational studies dosing IOPIDINE Ophthalmic Solution once or twice daily for up to 28 days in nonlaser studies:
Ocular: Conjunctival blanching, upper lid elevation, mydriasis, burning, discomfort, foreign body sensation, dryness, itching, hypotony, blurred or dimmed vision, allergic response, conjunctival microhemorrhage.
Gastrointestinal: Abdominal pain, diarrhea, stomach discomfort, emesis.
Cardiovascular: Bradycardia, vasovagal attack, palpitations, orthostatic episode.
Central Nervous System: Insomnia, dream disturbances, irritability, decreased libido.
Other: Taste abnormalities, dry mouth, nasal burning or dryness, headache, head cold sensation, chest heaviness or burning, clammy or sweaty palms, body heat sensation, shortness of breath, increased pharyngeal secretion, extremity pain or numbness, fatigue, paresthesia, pruritus not associated with rash.
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